Nitric Oxide Research
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 | THE 1998 NOBEL PRIZE WENT TO THREE AMERICAN SCIENTISTS FOR DISCOVERING THE TIE BETWEEN NITRIC OXIDE (NO) AND CARDIOVASCULAR HEALTH. THE FOLLOWING STUDIES CONFIRM THE NEED TO BOOST NO PRODUCTION IN YOUR BODY. |
Age-associated changes in nitric oxide metabolites nitrite and nitrate
Int J Clin Lab Res. 2000. 30:83-85.M. Toprakçı, D. Özmen, I. Mutaf, N. Turgan, Z. Parıldar, S. Habif, İ. Güner and O. Bayındır
Nitric oxide is essential in staving off cardiovascular risk factors such as aging, hypertension, and atherosclerosis. The aim of this study was to determine whether increased age resulted in decreased serum nitrite and nitrate levels—the end-products of nitric oxide—in healthy subjects. Healthy individuals were divided into five age groups and their serum nitrite and nitrate levels were measured. Analysis showed that nitrite levels were not significantly different, but nitrate concentrations exhibited significant differences. This suggests that nitric oxide synthesis is reduced with age, decreasing the vasodilation essential to vascular health.
Nitric oxide—from mediator to medicines
J R Coll Physicians Lond. 1994 May-Jun;28(3):209-19.Vallance P, Moncada S.
Nitric oxide is involved in a wide range of physiological processes in humans and animals. It controls vascular tone, acts as a neurotransmitter and neuromodulator in the central and peripheral nervous systems, and influences the activity of the immune system. Substances that selectively enhance or inhibit its synthesis or removal and modify its effects are likely to yield interesting therapeutic agents.
Nitric oxide: an antioxidant and neuroprotector
Annals of the New York Academy of Sciences. Volume 962. p 389. May 2002.Kochupurackal P. Mohanakumar, Bobby Thomas, Sudarshana M. Sharma, Dhanasekharan Muralikrishnan, Rukhsana Chowdhury, Chuang C. Chiueh
Evidence suggests that nitric oxide acts as a powerful antioxidant, protecting cells against neurotoxicity and other dangers. In vitro and in vivo laboratory results are reviewed to find the effects of nitric oxide on MPTP neurotoxicity and see what other protections nitric oxide may offer.
The discovery of nitric oxide as the endogenous nitrovasodilator
Hypertension. 1988 Oct;12(4):365-72.Moncada S, Palmer RM, Higgs EA
Nitric oxide is indentified as the key factor in relaxing arterial walls and keeping platelets operating at optimum levels and functionality. Research also indicates that L-arginine is the precursor for the synthesis of nitric oxide.
Endogenous nitric oxide-mediated relaxation and nitrinergic innervation in the rabbit prostate: The changes with aging
The Prostate. Volume 48, Issue 1, pages 40–46, 15 June 2001. DOI: 10.1002/pros.1079Ken Aikawa, Takashi Yokota, Hiro-oki Okamura, Osamu Yamaguchi
Nitric oxide plays the key role in the non-adrenergic non-cholinergic nerve-mediated relaxation of the prostate. This study evaluates whether nitrinergic innervation of the prostate is reduced with aging, and whether a reduction of this innervation alters the relaxant properties of prostatic tissue. Researchers found that both nitric oxide-mediated relaxation and nitrinergic innervation are reduced with aging in this animal model, confirming the body’s need for help in producing nitric oxide later in life.
L-Arginine Research
L-arginine Research
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| IN A RECENT STUDY AT COLUMBIA UNIVERSITY, RESEARCHERS CALLED L-ARGININE THE “MAGIC BULLET FOR THE CARDIOVASCULAR SYSTEM.” BELOW YOU’LL FIND THE LATEST RESEARCH DETAILING WHAT L-ARGININE CAN DO FOR YOU. |
Correction of endothelial dysfunction in chronic heart failure: additional effects of exercise training and oral L-arginine supplementation
J Am Coll Cardiol, 2000; 35:706-713Rainer Hambrecht, MDa, Lutz Hilbrich, MDa, Sandra Erbs, BSca, Stephan Gielen, MDa, Eduard Fiehn, MDa, Nina Schoene, MDa and Gerhard Schuler, MDa
40 patients with severe chronic heart failure were divided into groups to test the effects of L-arginine on vasodilation. The goal was to analyze whether L-arginine has comparable or additive effects to physical exercise. After four weeks of observation and study, researchers concluded that the effectiveness of L-arginine on vasodilation was similar to that of regular exercise, and that when exercise and L-arginine supplementation are combined, the effects are even greater.
Differential inhibition of human platelet aggregation and thromboxane A2 formation by L-arginine in vivo and in vitro
Naunyn-Schmiedeberg's Archives of Pharmacology. Volume 357, Number 2, 143-150.S. M. Bode-Böger, Rainer H. Böger, Andrea Galland, Jürgen C. Frölich
In a study of 20 healthy male volunteers, researchers used L-arginine and a placebo to determine the effects of L-arginine on platelet aggregation and thromboxane A2 formation in vivo and in vitro. The results indicated that the L-arginine/nitric oxide pathway is present in human platelets as a Ca2+-dependent anti-aggregatory pathway, and that in vivo the formation of nitric oxide from L-arginine by endothelial cells may contribute to these platelet-inhibitory effects.
L-arginine in the management of cardiovascular diseases
The Annals of Pharmacotherapy: Vol. 35, No. 6, pp. 755-764. DOI 10.1345/aph.10216JW Cheng, SN Baldwin, and SN Balwin
An in-depth look into five decades’ worth of l-arginine studies shows that l-arginine improves the management of multiple cardiovascular diseases. It has been demonstrated that intravenous L-arginine augments endothelial function by enhancing vasodilation and reducing monocyte adhesion, while oral supplementation demonstrated similar effects as well as improvement of exercise ability in patients with cardiovascular diseases.
L-arginine supplementation improves exercise capacity after a heart transplant
Am J Clin Nutr. 2010 May;91(5):1261-7. Epub 2010 Mar 3.Doutreleau S, Rouyer O, Di Marco P, Lonsdorfer E, Richard R, Piquard F, Geny B.
Researchers compared the exercise capacity in healthy subjects and heart transplant patients and investigated whether L-arginine supplementation might improve exercise capacity after a heart transplant. Subjects performed a 6-minute walk test and a maximal bicycle exercise test before and after a 6-week period of placebo intake or L-arginine supplementation. Unlike with the placebo intake, six weeks of L-arginine supplementation improved quality of life in heart transplant recipients—their submaximal exercise capacity increased, as did their distance walked during the 6-minute walking test.
L-arginine given after ischaemic preconditioning can enhance cardioprotection in isolated rat hearts
Eur J Cardiothorac Surg 2001;19:873-879.Yoshihiro Suematsua, Toshiya Ohtsukaa, Yasunobu Hiratab, Katsuhide Maedaa, Kazuhito Imanakaa, Shinichi Takamotoa
Isolated rat hearts were prepared and divided into six groups and treated with L-arginine to determine the effects on coronary flow. Nitrites and nitrates were measured 5 and 60 minutes after reperfusion, and infarct size was also determined. Results showed that enhancement of the effects of ischaemic preconditioning can be achieved with L-arginine, a precursor of nitric oxide, improving post-ischaemic functional recovery and infarct size in the isolated rat heart.
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